Grutte Pier [Wa Oars]

Grutte Pier [Wa Oars] Forum
Het is momenteel Di Mrt 20, 2018 21:18

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BerichtGeplaatst: Zo Mei 06, 2012 04:17 
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Geregistreerd: Do Dec 22, 2005 03:53
Berichten: 973
Woonplaats: Leeuwarden


Genomes are fantastic keepers of genetic information and are the outcome of evolutionary replication, mutation and selection.
Genomes organize functions from the cellular level, via the organismic level, up to the complex basis of mind. In human cells
the genetic information controlling most processes from the cellular level, over embryogenesis to cognitive ability, manifests in
a diploid set of 23 DNA molecules (chromosomes), combined they consist of ~3x10e9 base pairs (bp) stored in ~2.80 GB of
data. This whole genome, whose added molecular length totals ~2 m, is kept in comparably small cell nuclei with typical
diameters of ~10 µm or volumes of 500 µm3. The sequential organization of genomes, i.e. the relations between distant base
pairs and regions within sequences, and its connection to the three-dimensional architectural organization of genomes is still
a largely unresolved problem.


Correlizer has been set up to unravel these mysteries, and we found long-range power-law correlations on almost the entire
observable scale of 132 completely sequenced chromosomes of 0.5 x 10e6 to 3.0 x 10e7 bp. Varying from Archaea, Bacteria,
Arabidopsis thaliana, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster, and Homo sapiens.
The local correlation coefficients show a species-specific multi-scaling behavior: close to random correlations on the scale of a
few base pairs, a first maximum from 40 to 3,400 bp (for Arabidopsis thaliana and Drosophila melanogaster divided in two
submaxima), and often a region of one or more second maxima from 10e5 to 3 x 10e5 bp. Within this multi-scaling behavior,
an additional fine-structure is present and attributable to codon usage in all except the human sequences, where it is related to
nucleosomal binding.

Computer-generated random sequences assuming a block organization of genomes, the codon usage, and nucleosomal binding
explain these results. Mutation by sequence reshuffling destroyed all correlations. Thus, the stability of correlations seems to be
evolutionarily tightly controlled and connected to the spatial genome organization, especially on large scales.

In summary, we found that genomes show a complex sequential organization related closely to their three-dimensional
organization, which has resulted in entire new insights into genomes. This is important for the general understanding of genomes,
from which then new diagnostics and treatments can be developed. With modern high-throughput sequencing techniques now
entire genomes are sequenced on a daily basis for a very low price. Actually thousands of completely sequenced genomes fill the
public databases meanwhile. Consequently, the analysis of the genetic sequence gets more and more important as well.


Voer de onderstaande stappen uit voor het installeren van de client-software.
  1. Download en installeer BOINC
  2. Open BOINC Manager
  3. Voeg een nieuw project toe: Tools -> Attach to project or account manager...
  4. Selecteer Attach to project
  5. Voer Project URL in:
  6. Voer je gebruikersnaam en wachtwoord in (zie onder voor subteam-info)
  7. Grazen maar!


Mocht je namens Team GP willen crunchen, vul dan voor je BOINC accountnaam het volgende in:

Grutte Pier [Wa Oars]~<gebruikersnaam>

(dus bv. Grutte Pier [Wa Oars]~Gurbe)


Correlizer is een officieel DPC-project, maar er zijn geen DPCH-Stats.

Voor de stats zie: DigiK-oz - Correlizer


BerichtGeplaatst: Wo Aug 27, 2014 11:01 
Forum Admin

Geregistreerd: Do Dec 22, 2005 03:53
Berichten: 973
Woonplaats: Leeuwarden
Ik weet niet of dit project officieel is afgesloten, maar de website is compleet van de kaart verdwenen... :?

Dus vandaar verplaatst naar de sectie "Inactive".

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